Statistical Methods in Diagnostic Medicine(Third Edition)
Third Edition Awaiting Publication
About this book:
In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Third Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations.
Since the second edition, we have added four new chapters: Chapter 12 gives detailed instruction for location-specific ROC methods for diagnostic imaging, including the location receiver operating characteristic (LROC) curve, the free-response ROC (FROC) approach, and regions of interest (ROI). The theme of Chapter 13 is the technical performance (“accuracy”) of quantitative imaging biomarkers, which focuses on objective feature derived from an image and used as an indicator of normal or disease processes. Chapter 14 considers diagnostic clinical outcome studies of the effects of tests on patient outcomes, and discuss the related study designs and analysis methods. Chapter 16 considers the risk assessment problem, which is an important component in individualized medical decision making.
We have also updated each chapter with recently published methods. These updates include methods for verification restricted to screen positives, new methods for correcting for verification bias in estimation of ROC curves of continuous-scale tests, both new frequency methods and bayesian methods for correcting for imperfect standard bias, and new methods for publication bias.
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470906514
CODE:
We have written the software in R to implement many of the statistical methods discussed in this book. We present the R code of the methods introduce in each chapter of the third edition of this book below:
Chapter 4: /code_chapter4.zip
Chapter 5: /code_chapter5.zip
Chapter 6: /code_chapter6.zip
Chapter 8: /code_chapter8.zip
Chapter 9: /code_chapter9.zip
Chapter 10: /code_chapter10.zip
Chapter 11: /code_chapter11.zip
Chapter 12: /code_chapter12.zip
Chapter 13: /code_chapter13.zip
Chapter 14: /code_chapter14.zip
